Lefla-200

Description:

Ofloxacin is a quinolone antimicrobial agent. The mechanism of action of ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

 

Composition

 Ofloxacin 200 mg

Description

Ofloxacin is a quinolone antimicrobial agent. The mechanism of action of ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Indications

Acute Bacterial Exacerbations of Chronic Bronchitis, Community-acquired Pneumonia, Uncomplicated Skin and Skin Structure Infections ,Acute Uncomplicated Urethral and Cervical Gonorrhoea, Nongonococcal Urethritis and Cervicitis.Mixed Infections of the Urethra and Cervix,Acute Pelvic Inflammatory Disease Uncomplicated Cystitis, Complicated Urinary Tract Infections ,Prostatitis

Contraindications

Ofloxacin tablets are contraindicated in persons with a history of hypersensitivity associated with the use of ofloxacin or any member of the quinolone group of antimicrobial agents.

 

Special Precautions

Tendinitis and Tendon rupture, exacerbation of myasthenia gravis, Fever, rash, or severe dermatologic reactions (e.g. toxic epidermal necrolysis, Stevens-Johnson syndrome),Vasculitis; arthralgia; myalgia; serum sickness, Allergic pneumonitis, Interstitial nephritis; acute renal impairment or failure, Hepatitis; jaundice; acute hepatic necrosis or failure, Anaemia, including haemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leucopenia; agranulocytosis; pancytopenia; and/or other haematologic abnormalities.