Tablets

Composition

L-Methylfolate 1000mcg+Methylcobalamin 1500mcg+Pyridoxal-5-Phosphate 500mcg

Description

This is an oral combination of bioavailable B vitamins i.e L-methylfolate, methylcobalamin, and pyridoxal 5’-phosphate for improving epidermal nerve fiber density (ENFD) in the lower extremity of patients with diabetic peripheral neuropathy (DPN). Provides nutritional requirements needed to restore metabolic processes associated with diabetic neuropathy to maintain blood flow by increasing nitric oxide resulting in vasodilation. L-methylfolate Primary biologically active isomer of folic acid and the primary form of folate in circulation; folic acid is a precursor of tetrahydrofolic acid, which is involved as a cofactor for transformylation reactions. Pyridoxal 5’ phosphate (PLP) Active form of Vitamin B6. Methylcobalamin One of 2 forms of biologically active vitamin B12.

Indications

These tablets are indicated for the distinct nutritional requirements of patients with endothelial dysfunction who present with loss of protective sensation and neuropathic pain associated with diabetic peripheral neuropathy.
Pharmacology:
Methylcobalamin:
It is the potent form of vitamin B12   a vitamin that has strong effects on the brain and nervous system being also very important for cell growth and production.
L-Methylfolate:
L-Methylfolate is novel form of folate and is more effective than folic acid. It is critical factor in the reduction of ser um homocysteine levels, which studies have noted to be elevated in patients with diabetic neuropathy in comparison with patients with diabetes without neuropathy.
Pyridoxal-5 Phosphate:
Pyridoxal-5 Phosphate is the active form of vitamin B6 and is used as the prosthetic group for many of the enzymes where this vitamin is involved. PLP is readily absorbed by the intestine by a process which is proceded by dephosphorylation to form pyridoxal.
Vitamin D3 :
Vitamn D deficiency has been shown to be more common in diabetic patients who have symptoms of distal symmetrical polyneuropathy. Thus vitamin D3 helps in lowering risk of Vitamin D deficiency; an indepenedent risk factor for diabetic peripheral neuropathy.

Drug Interactions

Methylcobalmin: This includes prescription and over the counter (OTC) medications, supplements like vitamins and other dietary suppliments (neutritional shakes, protein powder, etc.), herbal drugs. Some medications that have serious interactions with vitamin B12 are: Chlorambucil, Omeprazole, colchicines. Pyridoxal-5-Phosphate: Drugs including Aspirin, anticoagulants (“blood thinners”) such as Warfarin or heparin, anti platelet drugs such as clopidogrel,  and non steroidal anti inflammatory drugs such as ibuprofen or naproxen. It may affect blood sugar level also.
VitaminD3 interacts with aluminium containing antacids and digoxin.
L-methyl folate calcium interacts with warfarin and anticonvulsants.

Warning and Precautions

Consult your Doctor or Pharmacist, before taking this combination if:

• You are allergic to any of its ingredient
• If you are pregnant, planning to become pregnant, or are breast feeding
• Patients with a history of bipolar illness.