Syrups

Composition

Amoxycillin 200mg 
Potassium Clavulanate 28.5mg

Description

Dry syrups are the mixtures that require the addition of water at the time of dispensing inadequate chemical stability of drug in aqueous vehicle to avoid the physical stability problem.

Indications

• Upper and lower respiratory tract infection
• Otitis Media (inflammation of the middle ear).
• Acute Sinusitis
• Acute exacerbation of chronic bronchitis
• Pneumonia
• Urinary tract infection 

Side Effects

• Diarrhea/loose stools 
• Nausea 
• Vomiting
• Headache 

Mode of Action

• Penicillin-like antibiotic Amoxicillin works by stopping the growth of bacteria 

• Potassium clavunate works by preventing bacteria from destroying amoxicillin.

Pharmacodynamics

Clavulanic acid binds and inhibits beta-lactamases that inactivate amoxicillin resulting in amoxicillin having an expanded spectrum of activity. Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

List of Contraindications

Amoxicillin and potassium clavunate is contraindicated in patients with a history of allergic reactions to any penicillin.

It is also contraindicated in patients with a previous history of cholestatic jaundice.

Drug Interactions

Before taking this medicine tell the doctor about any medical problems an allegries that child has now or has had. Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications.

Conclusion

From the above discussion, it can be concluded that this Amoxycillin and Potassium clavunate dry syrups could improve health of children from Urinary tract infection, Otitis Media and Upper and lower respiratory tract infection.