Injections

Composition

Ceftriaxone 250/500/1000 mg

Description

Ceftriaxone is a long acting, broad-spectrum cephalosporin antibiotic for parenteral use. The bactericidal activity of ceftriaxone results from inhibition of cell wall synthesis. Ceftriaxone exerts in vitro activity against a wide range of Gram-negative and Gram-positive microorganisms. Ceftriaxone is highly stable to most beta-lactamases, both penicillinases and cephalosporinases, of Gram-positive and Gram-negative bacteria.

Indications

Infections caused by pathogens sensitive to Ceftriaxone are:
•        Sepsis, Meningitis, Abdominal infections
•        Infections of the bones, joints, soft tissue, skin and of wounds
•        Infections in patients with impaired defence mechanisms, Renal and urinary tract infections
•        Respiratory tract infections, pneumonia, and ear, nose and throat infections, Genital infections, including gonorrhea

Mode of Action

Ceftriaxone is a long acting, broad-spectrum cephalosporin antibiotic for parenteral use. Ceftriaxone inhibits the bacterial cell wall synthesis leading to lysis of bacteria. The maximum plasma concentration after a single IM dose of 1 g is about 81 mg/L and is reached in 2-3 hours after administration. Ceftriaxone has shown excellent tissue and body fluid penetration after a dose of 1-2 g. On intravenous administration, ceftriaxone diffuses rapidly into the interstitial fluid, where bactericidal concentrations against susceptible organisms are maintained for 24 hours.

Adverse Effects

Ceftriaxone is generally well tolerated. During the use of ceftriaxone, the following side effects, which were reversible either spontaneously or after withdrawal of the medicine, have been observed:
• Loose stools or Diarrhea
• Nausea, Vomiting, Skin Reaction
• Headache and Dizziness

Drug Interactions

Before Taking the medicine tell the doctor about any medical problems and allergies that the patient has now or was having in past

Conclusion

From the above discussion, it can be concluded that this Ceftriaxone with Sulbactum improve the quality of life and help to cure Respiratory tract infection, Urinary tract infection, Skin and soft tissue infection, Bone and joint infection, Bacterial Septicaemia, Bacterial Meningitis, Surgical Prophylaxis.