Injections

Composition

Piperacillin 4gm+Tazobactam 0.5gm

Description

Piperacillin/Tazobactam is a combination antibiotic containing the extended-spectrum penicillin antibiotic piperacillin and the ?-lactamase inhibitor tazobactam.
Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. 
Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.

Indications

Adverse Effects

Piperacillin and tazobactam may cause side effects such as upset stomach , vomiting, unpleasant or abnormal taste, diarrhea, gas ,headache, constipation, insomnia, rash, itching skin, swelling, shortness of breath, unusual bruising or bleeding.

Dosages

2-4 times  daily

Contraindications

PIPTAZIN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors. Probenecid prolongs half lives of piperacillin and tazobactam. Increased risk of methotrexate toxicity when used together.

Precautions

Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.