Syrups

Composition

Cefixime: 50mg

Description

 

Cefixime is a semi-synthetic, oral third-generation cephalosporin, which has marked in vitro bactericidal activity against a wide variety of gram-positive and gram-negative organisms. Bactericidal action of cefixime results from inhibition of cell-wall synthesis. Ofloxacin is a quinolone antimicrobial agent. The mechanism of action of ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Indications

 Acute Bacterial Exacerbations of Chronic Bronchitis, Community-acquired Pneumonia, Uncomplicated Skin and Skin Structure Infections ,Acute Uncomplicated Urethral and Cervical Gonorrhoea, Nongonococcal Urethritis and Cervicitis. Mixed Infections of the Urethra and Cervix, Acute Pelvic Inflammatory Disease Uncomplicated Cystitis, Complicated Urinary Tract Infections ,Prostatitis .Uncomplicated Urinary Tract Infections,Upper Respiratory Tract Infections (URTI),  Otitis Media, Pharyngitis and Tonsillitis, Acute Exacerbations of Chronic Bronchitis  Uncomplicated Gonorrhoea.

 

Dosages

Twice daily

Contra-Indications

Ofloxacin tablets are contraindicated in persons with a history of hypersensitivity associated with the use of ofloxacin or any member of the quinolone group of    antimicrobial agents. Carbamazepine, Warfarin and Anticoagulants.

 

Special Precautions

Tendinitis and Tendon rupture, exacerbation of myasthenia gravis, Fever, rash, or severe dermatologic reactions (e.g. toxic epidermal necrolysis, Stevens-Johnson syndrome),Vasculitis; arthralgia; myalgia; serum sickness, Allergic pneumonitis, Interstitial nephritis; acute renal impairment or failure, Hepatitis; jaundice; acute hepatic necrosis or failure, Anaemia, including haemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leucopenia; agranulocytosis; pancytopenia; and/or other haematologic abnormalities.

Side-effects

Gastrointestinal Disturbances, Headache and dizziness,  rash, pruritus, drug fever and arthralgia, urticaria or angio-oedema, Thrombocytosis, thrombocytopenia, leucopenia, hypereosinophilia, neutropenia and agranulocytosis have been reported.

Pack Size

30ml