Tablets

Composition

Cefuroxime axetil

Description

Cefuroxime axetil  is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration. The in vivo bactericidal activity of cefuroxime axetil is due to its binding to essential target proteins and the resultant inhibition of cell-wall synthesis. Cefuroxime is bactericidal against a wide range of common pathogens, including many beta-lactamase–producing strains. It is stable to many bacterial beta-lactamases, especially plasmid-mediated enzymes that are commonly found in Enterobacteriaceae.

Indications

Pharyngitis/Tonsillitis, Acute Bacterial Otitis Media, Haemophilus influenzae (including beta-lactamase–producing strains), Moraxella catarrhalis (including beta-lactamase–producing strains), Acute Bacterial Maxillary Sinusitis. Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis, Uncomplicated Skin and Skin-Structure Infections, Uncomplicated Urinary Tract Infections, Uncomplicated Gonorrhea, Early Lyme disease (erythema migrans).

 

Dosages

Adolescents and Adults (13 years and older)

•      Pharyngitis/tonsillitis 250 mg b.i.d.
•      Acute bacterial maxillary sinusitis 250 mg b.i.d.
•      Acute bacterial exacerbations of chronic bronchitis 250 or 500 mg b.i.d.
•      Secondary bacterial infections of acute bronchitis 250 or 500 mg b.i.d.
•      Uncomplicated skin and skin-structure infections 250 or 500 mg b.i.d.
•      Uncomplicated urinary tract infections 250 mg b.i.d.
•      Uncomplicated gonorrhea 1,000 mg once single dose
•      Early Lyme disease 500 mg b.i.d.

 

Contraindications

Patients with known hypersensitivity to cephalosporin antibiotics.

Special Precautions

Anaphylactic reaction to penicillin. Pseudomembranous colitis Over growth of non susceptible organisms.

•     Paediatrics: Not safe in children below 3 months.
•     Pregnancy: Use with caution.
•     Lactation: Use with caution.

 

Side Effects

Skin rashes, Eosinophilia and transient increase of hepatic enzymes.

Drug Interactions

Synergy with aminoglycosides.